The Muscle Metabolome Differs between Healthy and Frail Older Adults

Physical Activity in Non-Frail and Frail Older Adults

INTRODUCTION Physical activity (PA) is important for healthy ageing. Better insight into objectively measured PA levels in older adults is needed, since most previous studies employed self-report measures for PA assessment, which are associated with overestimation of PA. AIM This study aimed to provide insight in objectively measured indoor and outdoor PA of older adults, and in PA difference...

Immunologic Changes in Frail Older Adults

UNLABELLED Several studies have shown a heightened inflammatory state in frail older adults, marked by high serum levels of interleukin-6 and C-reactive protein and an increased number of circulating leukocytes. Activation of monocytes and macrophages, marked by increased levels of neopterin, may contribute to chronic inflammation in the frail older adult. However, the reduced mononuclear cell ...

Sleep disorders and their impacts on healthy, dependent, and frail older adults.

BACKGROUND Sleep disorders differ widely in the heterogeneous older adult population. Older adults can be classified into three groups based upon their overall level of disability: healthy, dependent, and frail. Frailty is an emerging concept that denotes older persons at increased risk for poor outcomes. OBJECTIVE The aim of this consensus review is to describe the sleep disorders observed i...

Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.

Repair of skeletal muscle after injury is a key aspect of maintaining proper musculoskeletal function. Studies have suggested that regenerative processes, including myogenesis and angiogenesis, are impaired during advanced age, but evidence from humans is limited. This study aimed to compare active muscle regeneration between healthy young and older adults. We evaluated changes in clinical, bio...

Title Differences in muscle coactivation during postural control between healthy older and young adults